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Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements
Srushti Tambe1, Divya Jain1, Sai Kishore Meruva2
1Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Mumbai 400019, India.
Pharmaceutics
|October 27, 2022
Summary
Amorphous solid dispersions (ASDs) enhance drug solubility through advanced formulation and preparation methods. Recent characterization techniques offer deeper insights into ASD microstructure and performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Amorphous solid dispersions (ASDs) are a key technology for enhancing drug solubility.
- Formulation development for ASDs has evolved significantly since the 1960s.
Purpose of the Study:
- To review recent advancements in amorphous solid dispersions.
- Highlight progress in formulation approaches, preparation methods, and characterization techniques.
Main Methods:
- Review of solvent-based and solvent-free preparation methods (e.g., hot melt extrusion).
- Exploration of single vs. multiple polymeric carriers with plasticizers.
- Discussion of advanced characterization techniques (e.g., nano-tomography, TEM, AFM).
Main Results:
- Evolution from solvent-based to solvent-free preparation methods.
- Advancement in formulation strategies using single/multiple carriers and plasticizers.
- Development of novel characterization tools for microstructure analysis.
Conclusions:
- Significant progress in ASD formulation, preparation, and characterization.
- Specialty excipients and advanced analytical techniques are crucial for optimizing ASDs.
- Continued innovation promises improved drug delivery systems.
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