Therapies Based on Adipose-Derived Stem Cells for Lower Urinary Tract Dysfunction: A Narrative Review

Area of Science:

• Regenerative Medicine
• Urology
• Biomaterials Science

Background:

• Lower urinary tract dysfunction necessitates tissue repair or replacement.
• Current treatments using autologous tissues or synthetic materials face complications like immune rejection.
• Stem cell therapies present a promising alternative for treating lower urinary tract dysfunction.

Purpose of the Study:

• To explore the potential of adipose-derived stem cells (ASCs) for treating lower urinary tract dysfunction.
• To highlight the regenerative capabilities of ASCs and their application in tissue engineering.
• To assess the impact of ASC-based therapy on reconstructive urology.

Main Methods:

• Utilizing adipose tissue as a source for stem cells due to accessibility and safety.
• Investigating the in vivo regenerative mechanisms of ASCs, including paracrine activities and multi-differentiation potential.
• Conjugating ASCs with biomaterial scaffolds for tissue engineering applications.

Main Results:

• Adipose-derived stem cells (ASCs) possess significant regenerative capabilities.
• ASCs demonstrate strong regenerative potential, multi-differentiation capacity, and favorable cell-matrix interactions.
• Biomaterial scaffolds combined with ASCs form an effective tissue engineering strategy.

Conclusions:

• ASC-based therapy is a promising approach for lower urinary tract dysfunction.
• This therapy offers a viable alternative to current treatments, minimizing complications and immune rejection.
• ASC-based tissue engineering holds significant potential for advancing reconstructive urology.