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Updated: Aug 23, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
Nassim Kamar1,2,3, Arnaud Del Bello1,2, Florence Abravanel2,3,4
1Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, 31400 Toulouse, France.
Abstract:
Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.
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