Related Experiment Video
Updated: Aug 23, 2025
07:01
A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
1.5K
Kidney diseases and long non-coding RNAs in the limelight
Chenxin Liu1, Kuai Ma2, Yunchao Zhang1
1Reproductive and Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in Physiology
|October 27, 2022
Summary
Long non-coding RNAs (lncRNAs) are key regulators of gene expression with diverse roles. This review explores their function in kidney diseases, highlighting their potential as diagnostic biomarkers and therapeutic targets.
Area of Science:
- Genomics
- Molecular Biology
- RNA Biology
Background:
- Protein-coding genes are well-studied, but non-coding sequences, including long non-coding RNAs (lncRNAs), are increasingly recognized for their regulatory roles.
- lncRNAs, transcripts over 200 nucleotides, are involved in gene regulation at multiple levels, from epigenetics to intracellular transport.
- Dysregulation of lncRNAs is implicated in various diseases, particularly cancers and conditions involving genomic imprinting.
Purpose of the Study:
- To review the molecular mechanisms of lncRNAs in the context of kidney diseases.
- To summarize the impact of lncRNAs on kidney disease pathophysiology and complications.
- To evaluate the potential of lncRNAs as biomarkers for kidney disease prevention and prognosis, and as therapeutic agents.
Main Methods:
- Literature review of studies investigating lncRNAs and kidney diseases.
- Analysis of molecular mechanisms underlying lncRNA function in renal pathophysiology.
- Synthesis of evidence on lncRNA roles in disease progression and patient outcomes.
Main Results:
- lncRNAs play significant roles in regulating gene expression relevant to kidney function and disease.
- Specific lncRNAs are dysregulated in various kidney diseases, contributing to their development and progression.
- lncRNAs show promise as sensitive biomarkers for early detection and prognosis of kidney ailments.
Conclusions:
- lncRNAs represent a critical class of molecules with substantial implications for kidney disease research.
- Understanding lncRNA mechanisms offers insights into disease pathogenesis and identifies potential therapeutic strategies.
- lncRNAs hold significant promise as novel biomarkers and therapeutic targets for managing kidney diseases.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
01:10Nephrons
3.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.3K
01:20Types of RNA
6.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
6.1K
01:25Chronic Kidney Disease I: Introduction
56
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
56
01:28Chronic Kidney Disease III: Interprofessional Care
70
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
70
01:28Kidney Transplant I: Introduction
42
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
42