Related Experiment Video

Updated: Aug 23, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.5K

Research on the Correlation of Peripheral Blood Inflammatory Markers with PCT, CRP, and PCIS in Infants with

Linwei Li1, Hongyun Miao2, Xue Chen1

  • 1Department of Pediatrics, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China.

Evidence-Based Complementary and Alternative Medicine : Ecam
|October 27, 2022
PubMed

Insights

Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) are elevated in infants with community-acquired pneumonia (CAP). These markers correlate with disease severity and can aid in early diagnosis.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Immunology

Background:

  • Community-acquired pneumonia (CAP) is a common infection in infants.
  • Accurate and early diagnosis of CAP is crucial for effective treatment.
  • Biomarkers reflecting systemic inflammation can aid in diagnosing and assessing CAP severity.

Purpose of the Study:

  • To investigate the relationship between peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) and inflammatory markers (procalcitonin [PCT], C-reactive protein [CRP]) and clinical severity scores (pediatric critical illness score [PCIS]) in infants with CAP.
  • To evaluate the diagnostic and prognostic value of NLR, PLR, and SII in infants with CAP.

Main Methods:

  • A case-control study involving 100 infants with bacterial CAP and 100 healthy controls.
  • Measurement of peripheral blood NLR, PLR, and SII in both groups.
  • Measurement of serum PCT, CRP, and PCIS in the CAP group.
  • Correlation analysis using Spearman's method and receiver operating characteristic (ROC) curve analysis.

Main Results:

  • Infants with CAP exhibited significantly higher NLR, PLR, and SII compared to controls (P < 0.05).
  • ROC analysis indicated high diagnostic accuracy for NLR (AUC=0.934), SII (AUC=0.882), and PLR (AUC=0.737) for CAP.
  • NLR, PLR, and SII positively correlated with PCT and CRP, and negatively with PCIS, suggesting a link to inflammation and disease severity.

Conclusions:

  • NLR, PLR, and SII are significantly elevated in infants with CAP.
  • These inflammatory indices show potential as biomarkers for early diagnosis and assessment of disease extent in pediatric CAP.
  • NLR and SII demonstrate particular utility in guiding early diagnosis and severity assessment for CAP in infants.
Abstract

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

11.9K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.0K

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
363
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
164
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
302
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
19
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
429