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Rhinosinusitis: clinical-based phenotyping.

Giorgio Ciprandi1, Desiderio Passali2, Luisa Maria Bellussi3

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Rhinosinusitis (RS) management can be improved by a new clinical phenotyping system. This approach guides tailored treatments, including phytomedicines and bacteriotherapy, for better patient outcomes.

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Area of Science:

  • Otolaryngology
  • Medical Research

Background:

  • Rhinosinusitis (RS) is a prevalent condition with existing classifications like acute RS (ARS) and chronic RS (CRS).
  • Current classifications may not fully capture the diverse clinical presentations observed in practice.

Purpose of the Study:

  • To propose a novel, clinically-based phenotyping system for rhinosinusitis.
  • To enhance the diagnostic and therapeutic strategies for RS.

Main Methods:

  • Review and analysis of existing RS classifications and clinical observations.
  • Development of a new phenotyping framework based on clinical characteristics.

Main Results:

  • Introduction of new clinical phenotypes: simple catarrhal RS, Acute RS, acute bacterial RS, severe (complicated) acute RS, chronic RS, and recurrent chronic RS.
  • Emphasis on tailoring treatment strategies to specific clinical phenotypes.

Conclusions:

  • A thorough diagnostic work-up is essential for effective RS management.
  • Treatment decisions for RS should be primarily guided by the identified clinical phenotype.