[Immunological disorders in vitamin A and B1 deficiencies]

Atrophy of the thymus, mitogen-induced inhibition of T-lymphocyte blast-transformation, and decrease of the humoral immune response were observed in rats with alimentary vitamin A deficiency. Vitamin B1 deficiency induced by administration of oxythiamine led to the thymus atrophy, inhibition of T-lymphocyte blastogenic response in mice, and to suppression of delayed hypersensitivity in guinea pigs.