Related Experiment Video
Updated: Aug 23, 2025

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Enantioselective C-H Bond Functionalization Involving Arene Ruthenium(II) Catalysis
1Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China.
Abstract:
The p-Cymene ruthenium(II) complex is one of the most widely used catalysts in C-H activation. However, enantioselective C-H activation promoted by arene ruthenium(II) complexes has not been realized until recently. The revealed strategies include intramolecular nitrene C-H insertion, the use of chiral transient directing groups, chiral carboxylic acid, relay catalysis, and chiral arene ligands. In this minireview, these advances are summarized and discussed in the hope of spurring further developments.
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Radical Anti-Markovnikov Addition to Alkenes: Overview
Electrophilic Aromatic Substitution: Nitration of Benzene
Regioselectivity and Stereochemistry of Hydroboration
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...

