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Updated: Aug 23, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane
Tomaso Caporossi1,2, Lorenzo Governatori3, Gloria Gambini1,2
1Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Purpose:
To determine the efficacy of using a human amniotic membrane to close macular hole retinal detachment in highly myopic eyes.
Study Design:
Prospective, consecutive, nonrandomized interventional study.
Methods:
We included 19 high myopic eyes from 19 patients affected by macular hole retinal detachment who had already undergone vitrectomy with internal limiting membrane peeling. The patients underwent vitrectomy with amniotic membrane transplant.
Results:
Primary success was achieved after 3 months in 89.5% (17 of 19 eyes) and final macular hole closure was obtained in 94.7% (18 of 19 eyes) of the patients. The final retinal reattachment rate was 100%. The final 12-month mean BCVA improved from 20/2000 (2 logMAR) to 20/250 (1.1 logMAR). OCT-angiography revealed a high correlation between the superficial and deep capillary plexus and the final BCVA.
Conclusion:
Human amniotic membrane patches can effectively repair macular hole retinal detachment in high myopic eyes in terms of anatomic results and BCVA recovery.
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