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Latest Trends in Nucleic Acids' Engineering Techniques Applied to Precision Medicine
1Bioengineering Department, Imperial College London, London, UK. glaucia.daconceicaopereira12@alumni.imperial.ac.uk.
Methods in Molecular Biology (Clifton, N.J.)
|October 27, 2022
Summary
Nucleic acids are revolutionizing advanced therapeutics and precision medicine. Advances in DNA and RNA analysis are enabling new treatments for cancer, genetic disorders, and viral infections.
Area of Science:
- Biotechnology
- Genomics
- Molecular Biology
Background:
- Genomic discoveries have enhanced understanding of genotype-phenotype relationships.
- Nucleic acid technologies are crucial for biomarker discovery and understanding cellular processes.
Purpose of the Study:
- To discuss advances in nucleic acid-based therapeutics and precision medicine.
- To highlight the role of genetic engineering in developing novel treatments.
Main Methods:
- Utilizing polymerase chain reaction (PCR) and Cre-Lox recombination for nucleic acid analysis.
- Employing DNA and RNA sequencing and profiling techniques.
- Investigating gene delivery methods for therapeutic applications.
Main Results:
- Nucleic acids show significant potential in treating cancer, viral infections (e.g., mRNA vaccines for SAR-COV-2), and genetic disorders.
- Progress in nucleic acid delivery is overcoming therapeutic limitations.
- Epigenetic factors linked to disease are being tracked using nucleic acid profiling.
Conclusions:
- Nucleic acid-based biotechnologies are transformative for advanced therapeutics and precision medicine.
- Continued research in genetic engineering and delivery systems will expand therapeutic options.
Keywords:
CRISPR-Cas9Cancer researchCre-Lox recombinationDNAGenetic engineeringInfectologyMetabolic diseasesNanotechnologyNucleic acidsPrecision medicineRNAMore Related Videos
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