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Case Report of COVID-19 mRNA Vaccine-Associated Myocarditis

Thomas Licata1, Adam Clements2,3

  • 1Wisconsin Northern and Central GME Consortium, Wausau, Wisconsin, thomas.licata@aspirus.org.

WMJ : Official Publication of the State Medical Society of Wisconsin
|October 27, 2022
PubMed
Abstract

Insights

A rare case of myopericarditis developed in a young male days after his second dose of the Pfizer-BioNTech COVID-19 vaccine. Symptoms resolved with treatment, and cardiac function returned to normal.

Area of Science:

  • Cardiology
  • Vaccinology
  • Immunology

Background:

  • A case report details a 19-year-old male who developed myopericarditis shortly after receiving the Pfizer-BioNTech COVID-19 vaccine.
  • This event occurred in the context of rare adverse events reported following widespread mRNA vaccine administration.

Approach:

  • The patient presented with chest pain, elevated troponins, and reduced systolic function on echocardiogram, indicative of myocarditis.
  • Diagnostic workup included electrocardiogram and echocardiogram to assess cardiac involvement.
  • Treatment involved colchicine, ibuprofen, and proton pump inhibitors.

Key Points:

  • The patient experienced symptoms consistent with myopericarditis within two days of his second Pfizer-BioNTech vaccine dose.
  • Cardiac function and symptoms fully resolved within 32 days of treatment.
  • The Vaccine Adverse Event Reporting System plays a crucial role in identifying rare vaccine complications.

Conclusions:

  • The temporal association suggests a likely causal link between the mRNA vaccine and the patient's myopericarditis.
  • Further research is needed to elucidate the pathophysiology, incidence, and prevalence of vaccine-induced myopericarditis.
  • Understanding these rare complications is vital for ongoing vaccine safety surveillance.

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