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Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
Proofreading01:43

Proofreading

Overview
Feedback Loops01:01

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Hypothesis: Accept or Fail to Reject?01:17

Hypothesis: Accept or Fail to Reject?

The outcome of any hypothesis testing leads to rejecting or not rejecting the null hypothesis. This decision is taken based on the analysis of the data, an appropriate test statistic, an appropriate confidence level, the critical values, and P-values. However, when the evidence suggests that the null hypothesis cannot be rejected, is it right to say, 'Accept' the null hypothesis?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null hypothesis and 'fail to...
Journal Bearings01:23

Journal Bearings

Journal bearings are mechanical components that support and provide lateral stability to rotating shafts and axles. They are crucial in reducing friction, wear, and vibration in machinery such as engines, turbines, and pumps. The principle behind journal bearings is forming a thin lubricant film between the bearing surface and the rotating shaft, which minimizes direct contact and reduces frictional forces.
To better understand the concept of journal bearings, consider a rope winch with dry or...

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Related Experiment Video

Updated: May 13, 2026

Assay for Adhesion and Agar Invasion in S. cerevisiae
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Journal declares an end to accepting or rejecting papers.

Jeffrey Brainard

    Science (New York, N.Y.)
    |October 27, 2022
    PubMed
    Summary

    eLife will now charge a $2000 fee for peer review of selected submissions. Accepted papers and their critiques will then be made freely accessible to the public.

    Area of Science:

    • Scholarly publishing
    • Scientific communication
    • Open science initiatives

    Background:

    • Traditional academic publishing models often involve lengthy review processes and restricted access to research findings.
    • The rising costs associated with publishing can be a barrier for researchers and institutions.
    • There is a growing demand for more transparent and accessible scientific discourse.

    Discussion:

    • eLife's new model introduces a fee for peer review, aiming to cover costs while ensuring quality.
    • The journal will make both the final manuscript and the peer review reports openly available.
    • This approach seeks to balance financial sustainability with the principles of open access and transparent evaluation.

    Key Insights:

    • A shift towards a fee-based peer review system in a prominent scientific journal.

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  • Commitment to immediate open access for both research papers and critical reviews.
  • Potential impact on author submission choices and the broader landscape of scientific publishing.

    • Outlook:

    • This model could influence other journals considering alternative funding and open access strategies.
    • The long-term effects on research accessibility and the economics of scientific publishing will be monitored.
    • Further analysis will be needed to assess the adoption and success of this hybrid publishing approach.