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Updated: Aug 23, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Bacteriological Profiles in Early-Onset-Sepsis (EOS) and Late-Onset-Sepsis (LOS) in Neonates.

B Ramly^1,2, C Vavasseur¹, S Knowles¹

¹National Maternity Hospital, Holles Street, Dublin, Ireland.

Irish Medical Journal

|October 27, 2022

Summary

This audit compared early-onset sepsis (EOS) and late-onset sepsis (LOS) bacteriology, finding Gram-positive organisms common in EOS and Gram-negative in LOS. Antibiotic resistance remains low, supporting current empiric treatment guidelines.

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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

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Published on: January 27, 2019

Area of Science:

Neonatal Medicine
Infectious Diseases
Microbiology

Background:

Neonatal sepsis, a serious infection, is categorized as early-onset sepsis (EOS) or late-onset sepsis (LOS).
Understanding the causative pathogens and their antibiotic susceptibility is crucial for effective empiric treatment strategies.

Purpose of the Study:

To analyze bacteriology profiles in EOS and LOS.
To compare identified microorganisms and antibiotic sensitivity against hospital guidelines for empiric sepsis treatment.

Main Methods:

Retrospective collection of neonatal microbiological data, including blood culture (BC) collection dates and patient's day of life.
Analysis of BC time to positivity and antibiotic susceptibility results.

Main Results:

In EOS, Gram-positive organisms (85.7%) predominated, with Group B Streptococcus (GBS) as the most common pathogen.
In LOS, Gram-negative organisms (56%) were more frequent than Gram-positive organisms (44%), with E. coli being the leading pathogen causing bloodstream infections (BSI).
All identified organisms demonstrated sensitivity to the antibiotics used per protocol.

Conclusions:

Escherichia coli is the most common pathogen in neonatal sepsis and remains sensitive to first-line antibiotics.
Group B Streptococcus continues to be the primary pathogen in early-onset sepsis.
The study indicates a low rate of antibiotic resistance, underscoring the importance of regular analysis of bacteriological and susceptibility patterns for optimizing infant sepsis treatment.