Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

48.0K
Overview
48.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LDH encapsulation and MpdsRNase disruption boost RNAi efficacy in Myzus persicae, with mRNA-miRNA profiles unraveling lethality by tandem dsRNA targeting MpEcR and MpdsRNase.

Pest management science·2026
Same author

HyperTRIBE identifies hepatic IGF2BP2/IMP2 targets <i>in vivo</i> and links IMP2 to autophagy.

NAR molecular medicine·2026
Same author

Machine-learning-assisted comparative analysis of rice growth and yield formation in field and plant factory systems.

Frontiers in plant science·2026
Same author

Targeting vaccine fusion proteins to APCs increases immunogenicity of adenoviral and mRNA-LNP vaccines.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Bacillus subtilis expressing double-stranded RNA induced RNA interference in Tribolium castaneum.

Pest management science·2026
Same author

Effects of social support and type D personality, with serial mediation by psychological resilience and positive coping styles - a cross-sectional study: Subjective well-being in hemodialysis patients.

Medicine·2026

Related Experiment Video

Updated: Aug 23, 2025

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections
07:55

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Published on: November 8, 2024

494

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.

Marie J Pauwels1, Junhua Xie1, Adam Ceroi1

  • 1VIB Center for Inflammation Research, VIB, Technologiepark-Zwijnaarde 71, 9052, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark-Zwijnaarde 71, 9052, Ghent, Belgium.

Biomaterials
|October 27, 2022
PubMed
Summary

Choroid plexus-derived extracellular vesicles (EVs) can naturally cross the blood-cerebrospinal fluid barrier. These EVs can deliver therapeutic cargo into the brain, offering a novel drug delivery strategy for neurological disorders.

Keywords:
Blood-cerebrospinal fluid (CSF) barrierBrain barriersBrain deliveryExtracellular vesicles (EVs)

More Related Videos

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.9K
Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
06:45

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

4.5K

Related Experiment Videos

Last Updated: Aug 23, 2025

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections
07:55

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Published on: November 8, 2024

494
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.9K
Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
06:45

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

4.5K

Area of Science:

  • Neuroscience
  • Biotechnology
  • Drug Delivery

Background:

  • Central nervous system (CNS) barriers, including the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier, restrict drug entry into the brain.
  • Developing effective drug delivery systems to overcome these barriers is crucial for treating neurological disorders.
  • The blood-CSF barrier, formed by choroid plexus epithelial cells, is an under-explored target for drug delivery platforms.

Purpose of the Study:

  • To investigate the potential of extracellular vesicles (EVs) derived from choroid plexus epithelial cells as a brain drug delivery system.
  • To determine if these EVs can cross the blood-CSF barrier and deliver cargo to the brain after peripheral administration.

Main Methods:

  • Isolation and characterization of extracellular vesicles (EVs) from choroid plexus epithelial cells.
  • Peripheral administration of these EVs in a preclinical model.
  • Assessment of EV biodistribution and cargo delivery to the brain.

Main Results:

  • Choroid plexus epithelial cell-derived EVs demonstrated the ability to reach the brain following peripheral administration.
  • These EVs successfully delivered functional cargo into the brain.
  • The EVs showed potential for targeting the blood-CSF interface.

Conclusions:

  • Choroid plexus-derived EVs represent a promising natural mechanism for brain drug delivery.
  • Targeting the blood-CSF barrier with these EVs offers a novel therapeutic strategy for neurological diseases.
  • Further research into EV-based drug delivery holds significant potential for CNS therapeutics.