Related Experiment Video
Updated: Aug 23, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Vaccination Trends and Family-Level Characteristics Associated With Incomplete or Delayed Childhood Immunizations:
Lauren M Zell-Baran1,2, Anne P Starling1,3,4, Deborah H Glueck3,5
1Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Childhood immunization schedule adherence is low in Colorado, with factors like parental education and household income influencing completion rates. Identifying at-risk families can improve vaccination coverage.
Area of Science:
- Pediatric Health
- Public Health
- Epidemiology
Background:
- Childhood immunizations are crucial for preventing infectious diseases.
- Adherence to recommended vaccination schedules is essential for community immunity.
- Understanding factors influencing immunization adherence is vital for public health initiatives.
Purpose of the Study:
- To assess family-level factors associated with adherence to childhood immunization schedules.
- To identify predictors of vaccination schedule completion in young children.
Main Methods:
- Prospective cohort study of 1,410 pregnant women in Denver, Colorado (2009-2014).
- Analysis of vaccination data for children aged 0-6 years.
- Logistic regression used to compare family-level factors influencing vaccine schedule adherence.
Main Results:
- Only 61.8% of children completed the full vaccination series, below national goals.
- Factors associated with non-adherence included in-utero smoke exposure, single-parent households, non-White ethnicity, mothers not working outside the home, and lower household income.
- Higher maternal education and older parental age were associated with increased likelihood of completing the vaccination series.
Conclusions:
- Specific family-level factors are significantly associated with childhood immunization schedule adherence.
- Findings can inform targeted interventions to improve vaccination rates in at-risk populations.
- Addressing barriers related to socioeconomic status and parental factors may reduce immunization hesitancy and increase access.
Related Concept Videos
Vaccinations
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Factors Affecting Illness
For instance, risk factors are connected to illness,...
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Bias in Epidemiological Studies

