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Updated: Aug 23, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Opioid MOP receptor agonists in late-stage development for the treatment of postoperative pain

Qiu Qiu1, Joshua Cj Chew1,2, Michael G Irwin2

  • 1Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, Special Administrative Region, Hong Kong, Kwai Tsing, China.

Expert Opinion on Pharmacotherapy
|October 27, 2022
PubMed
Abstract

Insights

Novel opioids show promise for postoperative pain management, offering improved safety and efficacy. While oliceridine and cebranopadol present potential benefits, morphine-6-glucuronide has not demonstrated significant advantages.

Area of Science:

  • Pharmacology
  • Pain Management
  • Drug Development

Background:

  • Opioids are crucial for postoperative analgesia, often used in multimodal approaches.
  • Development focuses on novel agents with improved safety and efficacy profiles.

Approach:

  • This review evaluates late-stage clinical trials of new opioid analgesics.
  • Pharmacokinetic properties, safety, tolerability, and efficacy for postoperative pain were assessed.

Key Points:

  • Oliceridine: A μ opioid receptor agonist with rapid onset and reduced adverse effects like respiratory depression and nausea.
  • Cebranopadol: A multi-acting receptor-targeted opioid (μ-opioid and NOP receptors) with potential for neuropathic pain and reduced abuse liability.
  • Morphine-6-glucuronide: An active metabolite of morphine showing limited benefit in postoperative pain.

Conclusions:

  • Oliceridine and cebranopadol represent promising advancements in opioid-based pain management.
  • Further research is needed to fully establish the clinical utility of these novel agents.
Keywords:
M6GMOP receptor agonistNOP receptor agonistsTRV130biased-signaling opioidscebranopadolmorphine-6-gluconuridemu opioid receptor agonistnew opioidsnovel opioidsoliceridinepostoperative pain

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