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Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
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Evolution of naturally arising SARS-CoV-2 defective interfering particles

Samer Girgis1, Zaikun Xu2, Spyros Oikonomopoulos3

  • 1Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.

Communications Biology
|October 27, 2022
PubMed
Summary

Defective interfering (DI) particles of SARS-CoV-2 were identified, losing most of their genome but still interfering with viral replication. These DI particles show potential as antiviral agents and gene delivery vehicles.

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