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HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
Sara Liest1, Iben Riishede Christiansen2,3, Lisbeth Prætorius4
1Department of Obstetrics and Gynecology, North Zealand Hospital, Hillerød, Denmark.
Failed gonadotropin-releasing hormone (GnRH) agonist trigger can be rescued by human chorionic gonadotropin (hCG) re-triggering. This approach led to successful oocyte retrieval and subsequent live births, preventing cycle cancellation.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization
Background:
- Failed gonadotropin-releasing hormone (GnRH) agonist trigger during oocyte retrieval is a rare but recurring challenge in assisted reproductive technology.
- This situation can lead to significant patient distress and potential cycle cancellation.
Observation:
- A case report detailing a patient experiencing a failed GnRH agonist trigger during an IVF cycle.
- The clinical team opted for a rescue strategy involving re-triggering with human chorionic gonadotropin (hCG).
Findings:
- The hCG re-triggering successfully enabled the retrieval of 25 oocytes.
- The patient subsequently achieved two consecutive live births following frozen-thawed single blastocyst transfers.
Implications:
- This case highlights the efficacy of hCG re-triggering as a rescue protocol for failed GnRH agonist triggers in IVF.
- Awareness and implementation of this strategy can prevent cycle cancellation and improve patient outcomes in fertility treatments.
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