Androgens, Endometriosis and Pain
Susan F Evans1, M Louise Hull1,2, Mark R Hutchinson1,3
1Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Frontiers in Reproductive Health
|October 28, 2022
Summary
Low androgen levels may link endometriosis and chronic pelvic pain in women. This research explores androgens' role in pain management and hormonal treatments for endometriosis.
Area of Science:
- Reproductive Endocrinology
- Pain Medicine
- Gynecology
Background:
- The relationship between androgens, endometriosis, and chronic pain is complex.
- Current treatments for endometriosis can significantly alter hormonal profiles.
- A disconnect exists between endometriosis lesion extent and reported pain levels.
Purpose of the Study:
- To explore the role of androgens in the etiology and management of dysmenorrhea and pelvic pain.
- To investigate the potential link between reduced androgen levels and endometriosis-associated pain.
- To examine how inflammation may affect androgen levels in women with pelvic pain.
Main Methods:
- Review of existing research presented at the World Endometriosis Congress 2021.
- Analysis of data published in the Journal of Pain Research.
- Exploration of clinical strategies for optimizing androgen levels.
Main Results:
- A strong inverse relationship was observed between androgen levels and monthly pelvic and period pain.
- Reduced androgen levels may be a mechanism connecting endometriosis development and chronic pain.
- Evidence suggests a role for androgens in managing dysmenorrhea and pelvic pain.
Conclusions:
- Androgens may play a protective role against pelvic pain and dysmenorrhea, with or without endometriosis.
- Clinicians should consider optimizing androgen levels in women with these conditions.
- Further research is needed to understand if androgens are protective or if estrogens predispose to pain.
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