Frequency of Metabolic Syndrome in Paget's Disease of Bone

Our aim is to verify the prevalence of metabolic syndrome (MetS) in Paget's disease of bone (PDB) and to reveal the relationship between MetS and bone alkaline phosphatase (ALP) levels.

Twenty-three patients with PDB and 30 healthy subjects matched with age, sex, and body mass index (BMI) were recruited from the outpatient clinics of endocrinology. The ınternational diabetes federation -2006 MetS criteria were used for the evaluation of all participants. PDB group and control group were compared in terms of MetS and metabolic components of MetS and bone mineral metabolism parameters.

When the two groups were compared in terms of weight, waist circumference, BMI, and systolic blood pressure (p=0.09, p=0.644, p=0.78, and p=0.058, respectively), no statistically significant difference was found. The frequency of impaired fasting glucose (IFG) and diabetes mellitus (DM) was determined as 30% (7/23) in the PDB group. There were no patients in the control group with IFG and DM diagnosis. The frequency of IFG and DM was statistically higher in the PDB group than controls (p=0.002). The frequency of MetS was statistically higher in the PDB group than the controls. (73.91%, (17/23) vs.30% (9/30); p<0.01). There was a correlation between ALP level and hypertension medication (p=0.0045, r=0.27).

Patients with PDB seem to have MetS more frequently, these patients also should be monitored for MetS.