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Updated: Aug 23, 2025

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Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies

Ting Shao1, Xiling Jiang2,3, Guochang Bao4,5

  • 1Department of Gynecology, Affiliated Hospital of Chifeng University, Chifeng 024000, China.

Disease Markers
|October 28, 2022
PubMed

Insights

Xenopus kinesin-like protein 2 (TPX2) is overexpressed in most cancers and linked to poor prognosis. This study reveals TPX2 as a potential pan-cancer prognostic biomarker and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Mitosis and spindle assembly depend on the microtubule-associated protein Xenopus kinesin-like protein 2 (TPX2).
  • TPX2 is highly expressed in several malignant tumors, but its precise role in cancer remains largely unknown.
  • Understanding TPX2's function in cancer is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To investigate the role of TPX2 in various cancer types using a comprehensive pan-cancer bioinformatic analysis.
  • To evaluate TPX2 as a prognostic biomarker across 33 cancer types.
  • To explore the association of TPX2 expression with tumor characteristics and the tumor microenvironment.

Main Methods:

  • Differential gene expression analysis across 33 cancer types.
  • Pan-cancer bioinformatic analysis including survival, tumor mutational burden, microsatellite instability, and immune cell infiltration data.
  • Gene set enrichment analysis (GSEA) to identify associated signaling pathways.

Main Results:

  • TPX2 was significantly overexpressed in all studied cancer types.
  • Increased TPX2 expression correlated with poor prognosis in most cancers.
  • TPX2 expression associated with clinical stage, microsatellite instability, tumor mutational burden, and immune cell infiltration in specific cancers.
  • GSEA implicated TPX2 in aminoacyl tRNA biosynthesis, a key tumor cell cycle pathway.

Conclusions:

  • TPX2 is a potential pan-cancer prognostic biomarker.
  • TPX2 expression is linked to critical cancer hallmarks and the tumor microenvironment.
  • TPX2 represents a promising therapeutic target for various cancers.

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