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[Congenital heart defects. Frequency at autopsy]
Zentralblatt Fur Allgemeine Pathologie U. Pathologische Anatomie
|January 1, 1987
Summary
Congenital heart disease (CHD) affects 26.5% of pediatric autopsies, with ventricular septal defects being most common. Most deaths occurred within the first year of life, often with associated cardiac or extracardiac anomalies.
Area of Science:
- Pediatric Pathology
- Cardiovascular Science
- Medical Genetics
Context:
- Autopsy data from 3,071 stillborns and children up to 16 years (1969-1983).
- Focus on congenital heart disease (CHD) prevalence and characteristics.
Purpose:
- To analyze the spectrum and frequency of congenital heart disease in a large pediatric autopsy cohort.
- To identify common CHD malformations, associated anomalies, and demographic patterns.
Summary:
- Congenital heart disease (CHD) was identified in 26.5% of pediatric autopsies.
- Ventricular septal defects, d-transposition of great vessels, tetralogy of Fallot, and aortic coarctations were most frequent.
- The majority of deaths (78.8%) occurred within the first year of life, with 20.1% in the perinatal period.
- Associated cardiac anomalies were present in 81.8% of CHD cases; extracardiac malformations occurred in 7.2%.
Impact:
- Provides crucial epidemiological data on pediatric CHD for pathology and cardiology research.
- Highlights the high rate of associated anomalies, emphasizing the complexity of CHD management.
- Informs clinical practice and future research directions in pediatric cardiovascular health.