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Updated: Aug 23, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
Cefazolin-induced hypoprothrombinemia
Mallory Smith1, James Doyle1, Cameron Crane1
1Department of Internal Medicine, Baylor Scott & White Medical Center - Temple, Temple, Texas.
Abstract:
Long-term antibiotic use can be associated with a myriad of side effects, ranging from relatively benign to life-threatening. The most common side effects of cephalosporins include dermatologic reactions and diarrhea. Here, we present a rarer side effect: a spontaneous retroperitoneal hematoma in the setting of cefazolin administration for vertebral osteomyelitis. Several cephalosporins have been implicated in coagulopathy secondary to hypoprothrombinemia. However, only a few case reports have implicated cefazolin, and all have occurred in the context of acute or chronic renal failure. Our case of cefazolin-induced coagulopathy occurred in a patient with normal renal function.
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