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Published on: October 3, 2019
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Erythema multiforme after third COVID-19 vaccination (Pfizer-BioNTech).
Sonali Batta1, Austinn C Miller2, Susuana Adjei2
1Texas A&M College of Medicine, Temple, Texas.
Proceedings (Baylor University. Medical Center)
|October 28, 2022
Summary
Erythema multiforme (EM) can occur after COVID-19 booster shots, even if previous doses caused no skin reactions. This case highlights the importance of monitoring for EM post-vaccination.
Area of Science:
- Dermatology
- Vaccinology
- Immunology
Background:
- COVID-19 vaccination programs aim for widespread immunity.
- Cutaneous adverse reactions to vaccines are monitored for safety.
- Erythema multiforme is an immune-mediated skin condition.
Observation:
- A patient developed erythema multiforme (EM) after receiving a third, or booster, dose of a COVID-19 vaccine.
- This individual had no prior skin reactions following the initial two vaccine doses.
Findings:
- This is the first reported instance of vaccine-associated erythema multiforme following a COVID-19 booster vaccination.
- The case demonstrates that EM can manifest after subsequent vaccine doses despite prior tolerance.
Implications:
- Healthcare providers should maintain vigilance for erythema multiforme in patients presenting after COVID-19 vaccination.
- The potential for delayed or booster-specific cutaneous reactions necessitates ongoing surveillance of vaccine safety.
- This finding underscores the importance of considering vaccination history in the differential diagnosis of erythema multiforme.
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