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Lymph Node Metastases Detection Using Gd2O3@PCD as Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic
Z Rasouli1,2, N Riyahi-Alam1,3,4, M Khoobi4,5
1Medical Physics & Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Contrast Media & Molecular Imaging
|October 28, 2022
Summary
This study introduces novel gadolinium oxide nanoparticles (Gd2O3@PCD) as a high-relaxivity contrast agent for magnetic resonance molecular imaging. These nanoparticles show promise for high-resolution detection of breast cancer lymph node metastasis in mice.
Area of Science:
- Biomedical Imaging
- Nanotechnology
- Oncology
Background:
- Axillary lymph node status is critical for breast cancer staging and prognosis.
- Conventional sentinel lymph node (SLN) localization methods are invasive and limited to surgical procedures.
Purpose of the Study:
- To develop and evaluate a novel hybrid gadolinium oxide nanoparticle coating with Cyclodextrin-based polyester (Gd2O3@PCD) as a high-relaxivity T1 magnetic resonance molecular imaging (MRMI) contrast agent (CA).
- To assess the efficacy of Gd2O3@PCD nanoparticles for detecting lymph node metastasis in a mouse model of breast cancer.
Main Methods:
- Synthesized Gd2O3@PCD nanoparticles with a particle size of 20-40 nm.
- Evaluated longitudinal relaxivity (r1) of Gd2O3@PCD and Gd-DOTA (Dotarem).
- Utilized 3D T1-weighted MRI in BALB/c mice with 4T1 cell-induced lymph node metastasis to measure contrast ratios (CR) and assess axillary lymph nodes.
Main Results:
- Gd2O3@PCD nanoparticles exhibited significantly higher longitudinal relaxivity (3.98 mM-1·s-1) compared to Gd-DOTA (2.71 mM-1·s-1).
- Gd2O3@PCD achieved a peak CR of 2.21 for lymph nodes and 2.54 for tumors, outperforming Dotarem (0.40 for lymph nodes, 1.21 for tumors).
- High-resolution detection of lymph node metastasis was achieved, with improved visibility of lumbar-aortic lymph nodes.
Conclusions:
- Gd2O3@PCD nanoparticles serve as effective novel MRMI contrast agents for high-resolution detection of lymph node metastasis in mice.
- This approach holds potential for advancing breast cancer diagnostic imaging by enabling precise detection of metastatic spread.
