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Updated: Aug 23, 2025

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Silylated biomolecules: Versatile components for bioinks.

Titouan Montheil^1,2, Matthieu Simon^1,3, Danièle Noël³

¹IBMM, University Montpellier, CNRS, ENSCM, Montpellier, France.

Frontiers in Bioengineering and Biotechnology

|October 28, 2022

Summary

This summary is machine-generated.

This review explores sol-gel inorganic polymerization for creating advanced bioinks. This method enables cell encapsulation and versatile functionalization for tissue engineering applications.

Keywords:

bioorthogonal reaction bioprinting hybrid oligosaccharide hybrid peptide multifunctional hydrogel sol-gel

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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

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Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Published on: May 2, 2020

Area of Science:

Biomaterials Science
Chemical Engineering
Tissue Engineering

Background:

Natural biopolymer hydrogels are common bioinks but lack mechanical strength for demanding applications.
Covalent chemical hydrogels offer improved durability and stiffness but require cell-compatible crosslinking reactions.
Existing bioink research often overlooks developing new chemistries for cell encapsulation and versatile functionalization.

Purpose of the Study:

To review the sol-gel inorganic polymerization process for creating advanced bioinks.
To highlight the potential of sol-gel chemistry for cell encapsulation and versatile bioink functionalization.
To discuss the preparation and kinetic considerations of sol-gel-based hydrogels for bioprinting.

Main Methods:

Utilizing sol-gel inorganic polymerization as a chemoselective crosslinking reaction for hydrogel formation.
Optimizing biocompatible catalytic conditions for sol-gel reactions.
Silylating diverse biomolecules, including amino acids, peptides, proteins, and oligosaccharides, for bioink component development.

Main Results:

Sol-gel inorganic polymerization allows for the preparation of hydrogels with tunable mechanical properties.
The process is compatible with the encapsulation of living cells.
Silylated biomolecules can be readily incorporated, enabling versatile bioink functionalization.
The developed hydrogels support extrusion-based 3D bioprinting.

Conclusions:

Sol-gel inorganic polymerization presents a promising strategy for developing novel bioinks.
This approach offers a versatile platform for creating functionalized hydrogels for tissue engineering.
Further development of sol-gel chemistry can significantly advance the field of bioprinting.