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Association of plasma bone morphogenetic protein-4 levels with arterial stiffness in hypertensive patients

Ning Wang1,2, Ying Guo1,2, Ying Dong1,3,4

  • 1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Journal of Clinical Laboratory Analysis
|October 28, 2022
PubMed

Insights

Plasma levels of bone morphogenetic protein-4 (BMP-4) are higher in hypertensive individuals with arterial stiffness. Elevated BMP-4 indicates increased arterial stiffness, suggesting its potential as a predictive marker.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Hypertension Studies

Background:

  • Arterial stiffness is an early indicator of hypertension-related organ damage.
  • Bone morphogenetic protein-4 (BMP-4) may play a role in the interaction between hypertension and arterial stiffness.

Purpose of the Study:

  • To investigate the association between plasma BMP-4 concentrations and arterial stiffness in individuals with essential hypertension.
  • To determine if BMP-4 levels can predict arterial stiffness in hypertensive patients.

Main Methods:

  • 204 hypertensive individuals were categorized into high (abnormal) and low (normal) cardio-ankle vascular index (CAVI) groups.
  • Plasma BMP-4 levels were measured using ELISA.
  • Clinical characteristics and laboratory data were collected and analyzed.

Main Results:

  • Plasma BMP-4 levels were significantly higher in the high CAVI group compared to the low CAVI group.
  • BMP-4 concentrations showed a positive correlation with CAVI values in hypertensive individuals.
  • Elevated BMP-4 levels were independently associated with high CAVI, with a cutoff value of 33.34 pg/mL demonstrating predictive capability (AUC 0.751).

Conclusions:

  • Plasma BMP-4 levels are elevated in hypertensive individuals with increased arterial stiffness (high CAVI).
  • BMP-4 shows a strong correlation with CAVI, suggesting its potential as a predictive biomarker for arterial stiffness in hypertension.
Abstract

Keywords:
arterial stiffnessbiomarkerbone morphogenetic protein-4cardio-ankle vascular indexhypertension

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