Toxicological Advancements in Cocaine Detection: A Review

Area of Science:

• Forensic Toxicology
• Analytical Chemistry

Background:

• Cocaine (methyl benzoylecgonine) is a widely abused drug with a recent resurgence in consumption.
• This trend necessitates updated forensic approaches for detection and analysis.

Approach:

• The review focuses on the forensic analysis of cocaine, evaluating current detection methods.
• Emphasis is placed on immunological assays and liquid chromatography for biological sample analysis.

Key Points:

• Current drug tests can detect cocaine at concentrations lower than their positivity cut-off.
• Immunological assays are effective for screening oral fluid, hair, and post-mortem blood.
• Liquid chromatography offers high sensitivity, specificity, and rapid analysis with minimal sample preparation.

Conclusions:

• Advancements in analytical techniques improve forensic capabilities for cocaine detection.
• Ongoing research aims to further enhance sensitivity, reduce analysis time, and lower costs.