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Effect of Fibroblast Growth Factor-21 Molecule on Coronary CollateralDevelopment
Halil Fedai1, Mustafa Begenc Tascanov2
1Clinic of Cardiology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey.
Insights
Fibroblast growth factor-21 (FGF-21) is a significant predictor of coronary collateral formation in patients with coronary artery disease. Higher FGF-21 levels correlate with better collateral circulation, suggesting its role in myocardial function preservation.
Area of Science:
- Cardiology
- Vascular Biology
- Biochemistry
Background:
- Coronary artery disease (CAD) can lead to myocardial ischemia, where collateral arteries may preserve heart function.
- The development of these collateral arteries is crucial but not fully understood.
- No prior studies have explored the link between Fibroblast growth factor-21 (FGF-21) and coronary collateral circulation.
Purpose of the Study:
- To investigate the pathophysiology of coronary collateral development.
- To determine the relationship between FGF-21 levels and coronary collateral formation in patients with significant coronary artery stenosis.
Main Methods:
- A case-control study included 60 patients with ≥90% coronary artery stenosis and 30 controls.
- Coronary collateral circulation was assessed using the Rentrop-Cohen method.
- FGF-21 levels were measured, alongside demographic, echocardiographic, and laboratory data.
Main Results:
- FGF-21 levels were significantly higher in patients with coronary artery disease compared to controls (p=0.003).
- Individuals with good collateral circulation exhibited higher FGF-21 levels than those with poor collateralization (p=0.006).
- FGF-21 and C-reactive protein independently predicted collateral presence via logistic regression analysis.
Conclusions:
- FGF-21 is an independent predictor of coronary collateral formation.
- This study is the first to demonstrate a link between FGF-21 and collateral development.
- FGF-21 levels differ significantly between good and poor collateral formations, highlighting its potential role in cardiac prognosis.
Background:
Collateral arteries provide an alternative source to the myocardium resulting from ischemia due to occlusive coronary artery disease and may help preserve myocardial function in the case of coronary artery disease (CAD). Although collateral development is so important, its pathophysiology has not been fully elucidated. Till now, no study has investigated the relationship between Fibroblast growth factor-21(FGF-21) and coronary collateral.
Objective:
This study aims to investigate the pathophysiology of coronary collateral development.
Methods:
In our study, which we planned as a case-control, 60 consecutive patients with ≥90 stenosis in at least one large coronary artery as a result of coronary angiography (CAG) and 30 patients with normal coronary angiography were included in the study cross-sectional. Demographic, echocardiographic and laboratory data were recorded. Coronary collateral circulation was evaluated using the Rentrop-Cohen method. FGF-21 levels were measured in all individuals.
Results:
In the analysis, no significant difference was observed between the two groups in basic biochemical parameters other than HDL (p>0.05 for all). FGF-21 level was statistically significantly higher in the patient group compared to the control group (p: 0.003). Also, the FGF-21 level was found to be statistically significantly higher in the good collateral circulation group than the poor (p:0.006). Univariate and multivariate logistic regression analysis was performed to predict the presence of collateral. We found that FGF-21(p=0.006), and C-reactive protein (p=0.020) predicted the presence of collateral independently.
Conclusion:
Collateral formation and cardiac prognosis are closely related. Our study is the first to investigate the relationship between collateral formation and FGF-21. Our study showed that the FGF-21 level is an independent predictor of collateral formation. In addition, there was a significant difference between bad and good collateral formation regarding FGF-21 levels.
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