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Related Concept Videos

Other Glycolytic Pathways01:24

Other Glycolytic Pathways

128
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
128

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Related Experiment Video

Updated: Aug 23, 2025

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

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Published on: July 1, 2020

3.3K

Alternative pathway diagnostics.

Joshua M Thurman1, Veronique Fremeaux-Bacchi2

  • 1Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

Immunological Reviews
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

Monitoring the alternative pathway of the complement system is crucial for diagnosing and managing diseases driven by its uncontrolled activation. Diagnostic tests aid in risk prediction and guide therapy with new complement-blocking drugs.

Keywords:
alternative pathwayclinicaldiagnosticlaboratory

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Area of Science:

  • Immunology
  • Complement System Biology

Background:

  • Uncontrolled alternative pathway activation drives numerous diseases and contributes to others.
  • Diagnostic tests for the complement system's alternative pathway are vital.
  • Defects in alternative pathway regulation are significant disease risk factors.

Purpose of the Study:

  • To review the current landscape of diagnostic tests for the alternative pathway.
  • To highlight the role of genetic studies and imaging in assessing complement activation.
  • To emphasize the clinical utility of these tests in disease diagnosis and treatment.

Main Methods:

  • Review of diagnostic assays measuring alternative pathway function and activation fragments.
  • Analysis of genetic studies identifying disease-associated variants in alternative pathway genes.
  • Discussion of emerging imaging modalities for detecting complement activation.

Main Results:

  • A variety of tests exist to evaluate alternative pathway function, constituents, and activation.
  • Genetic variations predict disease risk and prognosis.
  • New imaging techniques show potential for non-invasive detection of complement activation.

Conclusions:

  • Diagnostic tests are essential for diagnosing diseases linked to the alternative pathway.
  • Prognostic information and therapeutic guidance are provided by these tests.
  • Complement inhibitory drugs are entering clinical use, necessitating precise monitoring.