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Related Experiment Videos

Camilla Dalby Hansen1,2, Katrine Prier Lindvig1,2, Henning Grønbæk3,4

  • 1Center for Leverforskning, Afdeling for Medicinske Mavetarmsygdomme, Odense Universitetshospital.

Ugeskrift for Laeger
|October 28, 2022
PubMed
Summary

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The lancet. Gastroenterology & hepatology·2026

Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. Early detection of advanced fibrosis using non-invasive tests in primary care can improve patient outcomes and prevent cirrhosis.

Area of Science:

  • Hepatology
  • Internal Medicine
  • Public Health

Context:

  • Non-alcoholic fatty liver disease (NAFLD) is a prevalent global health issue, impacting approximately 25% of the population.
  • Advanced fibrosis in NAFLD often presents late, with symptoms typically emerging during decompensated cirrhosis.
  • Current referral pathways may delay diagnosis and treatment for patients with advanced liver fibrosis.

Purpose:

  • To highlight the need for improved referral strategies for patients with NAFLD-related advanced fibrosis.
  • To introduce non-invasive testing methods for early identification of at-risk individuals.
  • To advocate for the integration of validated non-invasive tests in primary care settings.

Summary:

  • Non-invasive tests like FIB-4 and NFS can effectively identify patients with NAFLD at risk of advanced fibrosis in primary care settings.

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  • These tests facilitate timely referrals to secondary care for further evaluation and management.
  • Implementing these non-invasive markers can optimize patient management and potentially prevent disease progression.

    • Impact:

    • Enhancing early detection of advanced liver fibrosis in NAFLD patients.
    • Improving patient referral pathways from primary to secondary care.
    • Reducing the incidence of decompensated cirrhosis and its associated complications.