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Updated: Aug 23, 2025

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BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation

Lena Wischhof1, Hang-Mao Lee1, Janine Tutas1

  • 1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

The EMBO Journal
|October 28, 2022
PubMed
Summary

BCL7A regulates SWI/SNF/BAF complexes, impacting neural progenitor cell (NPC) differentiation and mitochondrial function. Its absence impairs neurogenesis and cognitive abilities, highlighting its role in neuronal development and brain function.

Keywords:
BCL7ASWI/SNF/BAF complexcognitive functionmitochondrial OXPHOSneural progenitor cells (NPCs)

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