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Related Concept Videos

Proteomics01:33

Proteomics

7.7K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Aug 23, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

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[Precision oncology from a proteogenomics perspective].

Yurou Huang1,2,3, Songfeng Wu2,3, Kunxian Shu1

  • 1School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

Precision medicine for cancer requires genomics, but proteogenomics offers a more comprehensive molecular analysis. This approach integrates proteomics and genomics to advance cancer precision oncology strategies.

Keywords:
cancerprecision oncologyproteogenomicspublic database

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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Last Updated: Aug 23, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

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Area of Science:

  • Oncology
  • Genomics
  • Proteomics

Background:

  • Cancer is a complex, heterogeneous disease necessitating targeted precision medicine.
  • Genomics is crucial for precision medicine but has limitations in molecular phenotype analysis.

Approach:

  • This review explores the limitations of genomic analysis in oncology.
  • It highlights the importance of proteogenomics, the integration of proteomics and genomics.
  • The review re-examines precision oncology through a proteogenomic lens.

Key Points:

  • Proteogenomics overcomes genomic limitations by combining proteomic and genomic data.
  • Applications of proteogenomics in precision oncology are discussed.
  • Relevant public proteogenomic data projects are outlined.

Conclusions:

  • Proteogenomics provides a deeper understanding of cancer biology for precision oncology.
  • Addressing current challenges is essential for the advancement of proteogenomic applications in cancer care.