Cyclopentolate eye drops-induced anaphylaxis in an infant

Area of Science:

• Ophthalmology
• Pediatric Allergy
• Clinical Pharmacology

Background:

• Cyclopentolate is a common mydriatic agent used in pediatric ophthalmology.
• Hypersensitivity reactions to cyclopentolate are documented but considered rare in children.
• This study focuses on a severe hypersensitivity reaction in an infant.

Observation:

• A nine-month-old infant with retinoblastoma developed urticaria, cough, stridor, and dyspnea post-cyclopentolate eye drop administration.
• The infant's symptoms were indicative of anaphylaxis.
• The patient was successfully treated with adrenaline.

Findings:

• The youngest pediatric patient to experience anaphylaxis from cyclopentolate eye drops is reported.
• Tropicamide was safely used as an alternative mydriatic agent during follow-up.
• This case highlights a rare but serious adverse drug reaction.

Implications:

• Clinicians should consider anaphylaxis in pediatric patients presenting with severe allergic symptoms after cyclopentolate use.
• Prompt recognition and management of cyclopentolate-induced anaphylaxis are crucial.
• Alternative mydriatic agents like tropicamide may be considered for hypersensitive patients.