Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosurgery01:30

Psychosurgery

96
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
96
Ethical Dilemmas II01:30

Ethical Dilemmas II

1.3K
Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
1.3K
Ethical Issues01:27

Ethical Issues

1.1K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
1.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

119
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
119
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

188
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
188
Ethical Dilemmas I01:17

Ethical Dilemmas I

1.0K
Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proposal for Circadian Rhythms and Their Behavioral Outputs as Biomarkers in <i>DSM-6</i>: Response to Cuthbert et al.

The American journal of psychiatry·2026
Same author

Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Mu-Opioid Signaling Engagement as a Candidate Maintenance Mechanism for Prolonging Ketamine's Antisuicidal Effects.

The American journal of psychiatry·2026
Same author

Major depressive disorder is associated with reduced intrinsic connectivity between the bed nucleus of the stria terminalis and ventral striatum.

Journal of psychiatry & neuroscience : JPN·2026
Same author

Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode: A Systematic Review and Meta-Analysis.

JAMA psychiatry·2026
Same author

Mechanistic Underpinnings of Emotional Face Processing in Suicide Risk: Exploring the Moderating Effects of Cortisol on Neural Parameters Using Magnetoencephalography.

Psychiatric research and clinical practice·2026

Related Experiment Video

Updated: Aug 23, 2025

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

12.3K

Irremediability in psychiatric euthanasia: examining the objective standard.

Marie E Nicolini1,2, E J Jardas1, Carlos A Zarate3

  • 1Department of Bioethics, National Institutes of Health, 10 Center Drive, Room 1C118, Bethesda, Maryland 20892, USA.

Psychological Medicine
|October 28, 2022
PubMed
Summary

Clinicians cannot accurately predict long-term recovery for individuals with treatment-resistant depression (TRD). This challenges the objective standard for irremediability in psychiatric euthanasia and assisted suicide (EAS) policies.

Keywords:
aid-in-dyingassisted suicideeuthanasiairremediabilityprecision psychiatrypsychiatrytreatment-resistant depression

More Related Videos

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.5K
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.7K

Related Experiment Videos

Last Updated: Aug 23, 2025

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

12.3K
In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.5K
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.7K

Area of Science:

  • Psychiatry
  • Medical Ethics
  • Clinical Psychology

Background:

  • Irremediability is a crucial criterion for psychiatric euthanasia and assisted suicide (EAS).
  • Current medical understanding requires clinicians to assess irremediability based on diagnosis and prognosis.
  • A clear, objective standard for irremediability in psychiatric EAS is needed for effective policymaking.

Approach:

  • A scoping review of PubMed was conducted using treatment-resistant depression (TRD) as a case study.
  • The review analyzed evidence on TRD definitions, long-term group outcomes, and the potential for accurate individual outcome prediction.
  • Key questions addressed whether clinicians can reliably identify irremediable cases of TRD.

Key Points:

  • A lack of a uniform definition for TRD exists, with over 150 variations identified, primarily in psychopharmacological research.
  • Limited studies on long-term outcomes suggest most patients with long-term TRD experience significant improvement over time.
  • While precision medicine advances individual prediction in TRD, methodological issues and variable accuracy hinder clinical implementation.

Conclusions:

  • Current evidence indicates clinicians cannot accurately predict long-term recovery for individual patients with TRD.
  • This inability to predict individual outcomes means the objective standard for irremediability cannot be met.
  • The findings have significant implications for the policy and practice of psychiatric EAS.