Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics.

Wonjun Yim¹, Jiajing Zhou², Lekshmi Sasi²

¹Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.

Advanced Materials (Deerfield Beach, Fla.)

|October 28, 2022

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discovery and characterization of hinokiflavone as a potent natural CD137 inhibitor for Kawasaki disease.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026

Same author

Integrated Microbiomics and Metabolomics Reveal That Moisture Content and <i>Lactiplantibacillus plantarum</i> Synergistically Regulate Fermentation Quality, Microbial Community, and Metabolite Profiles of Amaranth Silage.

Microorganisms·2026

Same author

Controlled Oxidation and Halide Coordination for Fractal Gold Nanoparticles with Applications in Photoacoustic Imaging.

ACS applied materials & interfaces·2026

Same author

Corrigendum to 'A brief strategy for the preparation of silk fibroin-copper sulfide-based electrospun nanofibrous membranes with photothermal antimicrobial properties to accelerate the infected wound healing' [Mater. Today Bio 31 (2025) 101605].

Materials today. Bio·2026

Same author

High frequency miniaturized transducer for facial and lingual full-mouth human imaging including third molars.

Biomedical optics express·2026

Same author

PROTOCOL: The Value of Rural Provider-To-Provider Telehealth for Emergency and Inpatient Care: An Evidence and Gap Map.

Campbell systematic reviews·2026

This summary is machine-generated.

Researchers created 3D-bioprinted skin phantoms across the Fitzpatrick scale to study skin phototypes in biomedical optics. These phantoms accurately mimic human skin

Area of Science:

Biomedical Optics
Bioprinting
Dermatology

Background:

Understanding the impact of diverse skin phototypes on biomedical optics is crucial for equitable technology development.
Current models often lack the complexity to accurately represent variations in human skin pigmentation.

Purpose of the Study:

To develop 3D-bioprinted skin phantoms that mimic various human skin tones (Fitzpatrick scale).
To investigate the influence of skin phototype on biomedical optics modalities.
To validate the optical properties and melanin mimicry of the fabricated phantoms.

Main Methods:

Fabrication of synthetic melanin nanoparticles (70-500 nm) and clusters to replicate melanosome optical behavior.
Characterization of phantom optical properties (absorption and reduced scattering coefficients) against human skin.

Keywords:

3D bioprinting artificial skins bioinspired materials biophotonic devices

More Related Videos

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Published on: August 22, 2018

Related Experiment Videos

Last Updated: Aug 23, 2025

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Published on: August 22, 2018

Validation of melanin content and distribution using photoacoustic (PA) imaging.

Application of various biomedical optics tools (PA imaging, fluorescence imaging, photothermal therapy) to assess skin tone impact.

Main Results:

The 3D-bioprinted phantoms exhibit absorption and reduced scattering coefficients comparable to real human skin.
Photoacoustic signal intensity in phantoms is significantly enhanced by increasing melanin size, clustering, and concentration.
Demonstrated the utility of these phantoms in understanding skin tone effects on PA imaging, fluorescence imaging, and photothermal therapy.

Conclusions:

3D-bioprinted skin phantoms with tunable melanin content and distribution provide a valuable tool for biomedical optics research.
These phantoms can help elucidate the impact of skin phototypes on optical modalities.
The development holds potential for advancing biomedical optics translation and mitigating racial bias in medical technologies.