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Long non-coding RNAs involved in retinoblastoma
Ava Nasrolahi1, Shirin Azizidoost2, Klaudia Radoszkiewicz3
1Infectious Ophthalmologic Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Journal of Cancer Research and Clinical Oncology
|October 28, 2022
Summary
Long non-coding RNAs (lncRNAs) show promise as biomarkers for retinoblastoma (RB), a common childhood eye cancer. These molecules regulate tumor growth, offering new therapeutic targets for RB treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Retinoblastoma (RB) is the most frequent pediatric retinal tumor, presenting in sporadic and heritable forms.
- Current treatments for RB necessitate the development of innovative strategies for childhood cancers.
Purpose of the Study:
- To review the emerging role of long non-coding RNAs (lncRNAs) in retinoblastoma.
- To explore lncRNAs as potential biomarkers and therapeutic targets for RB.
Main Methods:
- Literature review focusing on recent advancements in lncRNA research related to RB.
- Analysis of studies investigating the functions of lncRNAs in RB development and progression.
Main Results:
- Long non-coding RNAs (lncRNAs) are implicated as crucial regulators in retinoblastoma.
- lncRNAs function as either tumor suppressors or oncogenes by interacting with microRNAs (miRNAs) and transcription factors.
- lncRNAs demonstrate potential as diagnostic and prognostic biomarkers for RB.
Conclusions:
- lncRNAs play significant roles in modulating retinoblastoma through targeting miRNAs and transcription factors.
- The review highlights the dual function of lncRNAs (oncogenic or tumor-suppressive) in RB.
- lncRNAs represent a promising area for novel targeted therapies and biomarker development in retinoblastoma.
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