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The MATRICS Consensus Cognitive Battery: An Update.

Keith H Nuechterlein^1,2, Michael F Green^3,4, Robert S Kern^3,4

¹Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. keithn@ucla.edu.

Current Topics in Behavioral Neurosciences

|October 28, 2022

Summary

This summary is machine-generated.

The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative created the MATRICS Consensus Cognitive Battery (MCCB), a standard tool for assessing cognitive function in schizophrenia clinical trials.

Keywords:

Clinical trials Cognition International MATRICS Schizophrenia

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Area of Science:

Neuroscience
Psychiatry
Clinical Psychology

Background:

Schizophrenia is characterized by core cognitive deficits.
Standardized cognitive measures are needed for clinical trials.
The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative aimed to address this need.

Purpose of the Study:

To develop a standardized battery of cognitive measures for schizophrenia.
To facilitate reliable evaluation of interventions targeting cognitive deficits.

Main Methods:

NIMH-supported expert consensus meetings.
Empirical comparisons of candidate cognitive tests.
Selection of ten tests across seven cognitive domains for the MATRICS Consensus Cognitive Battery (MCCB).

Main Results:

The MATRICS Consensus Cognitive Battery (MCCB) was developed.
The MCCB is translated into 39 languages/dialects.
The MCCB has been utilized in over 145 clinical trials.

Conclusions:

The MCCB is the standard cognitive change measure for schizophrenia interventions.
It is used in studies of pharmacological and training-based interventions.
The MCCB's development influenced the NIMH RDoC Matrix.