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Related Experiment Video

Updated: Aug 23, 2025

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

New developments in translational microcirculatory research.

Gopika SenthilKumar^1,2,3, Cristhian A Gutierrez-Huerta^1,2,4, Julie K Freed^1,2,3

¹Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

American Journal of Physiology. Heart and Circulatory Physiology

|October 28, 2022

Summary

This summary is machine-generated.

Microvascular disease impacts organ function, but new research offers therapeutic strategies to improve microvessel health and reduce cardiovascular risks. Advances in translational microcirculatory research are key to preventing and treating these conditions.

Keywords:

clinical trial diabetes endothelial dysfunction hypertension microcirculation

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Last Updated: Aug 23, 2025

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Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

Cardiovascular Research
Translational Medicine
Microcirculation

Background:

Microvascular disease is a key factor in systemic end-organ dysfunction.
Treating microvascular pathologies can significantly reduce cardiovascular morbidity and mortality.

Purpose of the Study:

To summarize key advances in understanding microvessels' role in chronic diseases.
To highlight therapeutic strategies for enhancing microvascular function.

Main Methods:

Review of recent research on cutaneous, cerebrovascular, coronary, and peripheral microcirculation.
Inclusion of state-of-the-art reviews on endothelial function and microvascular health assessment.
Synthesis of original research on cellular, exosomal, pharmaceutical, exercise, heat, and dietary interventions.

Main Results:

Advances in understanding microcirculation's influence on obesity, hypertension, cardiovascular aging, peripheral artery disease, and cognitive impairment.
New insights into coronary endothelial function and microvascular health assessment across organ systems.
Evaluation of interventional therapies for microvascular health.

Conclusions:

Translational microcirculatory research provides a foundation for bench-to-bedside applications.
Preclinical models are crucial for mechanistic studies, but human-focused translation is essential for clinical strategies.
Future research should prioritize translating findings to develop effective clinical strategies for microvascular dysfunction.