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Related Experiment Video

Updated: Aug 23, 2025

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
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CD11c regulates neutrophil maturation.

Lifei Hou1,2, Richard A Voit3,4, Miho Shibamura-Fujiogi1,2

  • 1Cardiac Anesthesia Division, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.

Blood Advances
|October 28, 2022
PubMed
Summary
This summary is machine-generated.

CD11c regulates neutrophil maturation and function, crucial for combating sepsis. Activating CD11c enhances neutrophil effectiveness and bacterial eradication, offering a potential sepsis treatment target.

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Area of Science:

  • Immunology
  • Hematology

Background:

  • Sepsis management is currently conservative, with high morbidity and mortality.
  • Neutrophil production increases during sepsis, releasing immature cells with impaired function.
  • Mechanisms of neutrophil differentiation and maturation are not fully understood.

Purpose of the Study:

  • To investigate the role of CD11c in neutrophil maturation and function.
  • To explore CD11c as a potential therapeutic target for sepsis.

Main Methods:

  • Studied CD11c expression in neutrophils.
  • Utilized CD11c-deficient mice and constitutively active CD11c knock-in mice.
  • Administered lipopolysaccharide challenge to induce neutrophil production.

Main Results:

  • CD11c deficiency impaired neutrophil maturation, increasing preneutrophil proliferation and apoptosis, and reducing effector functions.
  • CD11c deficiency exacerbated the release of immature neutrophils during sepsis.
  • Constitutively active CD11c accelerated neutrophil maturation and enhanced effector functions and bacterial eradication.

Conclusions:

  • CD11c is critical for regulating neutrophil maturation and effector functions.
  • CD11c activation represents a promising therapeutic strategy for sepsis treatment.