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Related Experiment Videos

Neonatal tetanus treated with high dosage diazepam.

B H Khoo, E L Lee, K L Lam

    Archives of Disease in Childhood
    |September 1, 1978
    PubMed
    Summary

    This study investigated a combined treatment for neonatal tetanus using diazepam and phenobarbitone, finding it reduced mortality and the need for mechanical ventilation. Side effects like drowsiness and apnea were manageable by adjusting diazepam dosage.

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    Area of Science:

    • Neonatal Medicine
    • Pharmacology
    • Pediatric Critical Care

    Background:

    • Neonatal tetanus presents a significant mortality risk.
    • Effective management strategies for severe neonatal tetanus are crucial.

    Purpose of the Study:

    • To evaluate the efficacy and safety of a combined diazepam and phenobarbitone regimen for neonatal tetanus.
    • To assess the impact of this treatment on mortality and the requirement for artificial ventilation.

    Main Methods:

    • A cohort of 19 neonates with tetanus received continuous intravenous diazepam (20-40 mg/kg/day) and intragastric phenobarbitone (10-15 mg/kg/day).
    • Treatment outcomes, including mortality and need for mechanical ventilation, were recorded.

    Main Results:

    • The treatment regimen resulted in a mortality rate of 2/19 (11%).
    • The combination therapy appeared to decrease mortality and reduce the need for artificial ventilation.
    • Common side effects included profound drowsiness, coma, and reversible apnoeic episodes.

    Conclusions:

    • Combined intravenous diazepam and intragastric phenobarbitone is a potentially effective treatment for neonatal tetanus.
    • This regimen may lower mortality rates and decrease the reliance on mechanical ventilation in affected infants.
    • Careful monitoring and dose adjustment of diazepam are necessary to manage side effects such as respiratory depression.

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