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Impact of Moderate-Vigorous Physical Activity Trajectories on Colon Cancer Risk over the Adult Life Course
Cami N Christopher1,2, Charles E Matthews3, Pedro F Saint-Maurice3
1Department of Kinesiology and Public Health, California Polytechnic State University San Luis Obispo, San Luis Obispo, California.
Summary
Maintaining moderate-to-vigorous physical activity (MVPA) throughout adulthood is linked to a reduced risk of colon cancer. Decreasing activity levels, especially early in adulthood, may increase risk.
Area of Science:
- Epidemiology
- Public Health
- Cancer Research
Background:
- Moderate-to-vigorous physical activity (MVPA) is known to reduce colon cancer risk.
- The impact of MVPA timing across the adult life course on colon cancer risk remains unclear.
Purpose of the Study:
- To evaluate the association between maintaining and changing MVPA levels over time and colon cancer risk.
- To identify distinct patterns of MVPA trajectories throughout adulthood.
Main Methods:
- Analysis of 293,198 adults from the NIH-AARP Diet and Health Study (1995-2011).
- Utilized latent class trajectory models to identify MVPA patterns.
- Employed Cox proportional hazards regression to assess risk.
Main Results:
- Consistent high or moderate MVPA levels were associated with lower colon cancer risk compared to low MVPA.
- Increasing MVPA during adulthood was linked to reduced risk.
- Decreasing MVPA early in adulthood was associated with an increased colon cancer risk.
Conclusions:
- Consistent engagement in MVPA throughout adulthood may significantly reduce colon cancer risk.
- The timing and maintenance of physical activity are crucial factors in colon cancer prevention.
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