Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

EXTENDing the Role of Radiation in Oligometastatic Disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Same author

Genome-wide association study of never-smoking non-drinking young adults developing oral squamous cell carcinoma.

BMC cancer·2026

Same author

Defining the Role of SABR in Head and Neck Cancer: Results From a Multi-institutional Delphi Consensus.

International journal of radiation oncology, biology, physics·2026

Same author

Platform for the Evaluation of innovations in Radiation oncology through registry-based conduct of multi-centric pragmatic randomized trials: PERa implementation.

Trials·2026

Same author

Radiotherapy and Immune System Interactions Historical Perspectives and Clinical Advancements.

Molecular carcinogenesis·2026

Same author

Thermal Ablation and Rapid On-Site Cytology for Lung Nodules-A 'One-Stop Shop' Approach for Small Lesions: Experience in 8 Patients.

Journal of medical imaging and radiation oncology·2026

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

Oligometastases: Emerging Evidence.

Wei Liu¹, Houda Bahig², David A Palma³

¹Division of Radiation Oncology, BC Cancer Vancouver, Vancouver, BC, Canada.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|October 28, 2022

Summary

This summary is machine-generated.

Ablative therapies may cure limited metastatic disease, but evidence is evolving. Randomized trials are crucial for confirming the efficacy of metastasis-directed therapy in oligometastatic cancer.

More Related Videos

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Related Experiment Videos

Last Updated: Aug 23, 2025

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Area of Science:

Oncology
Cancer Metastasis Research
Clinical Trial Evidence

Background:

The concept of curing limited metastatic disease with ablative therapies has shifted cancer treatment paradigms.
Early evidence supporting ablative therapy efficacy was largely observational, lacking rigorous controls.
Recent randomized trials have provided new insights, challenging and affirming previous hypotheses.

Purpose of the Study:

To review the definition and challenges of identifying oligometastatic disease.
To summarize existing randomized trial evidence for metastasis-directed therapy in oligometastatic cancer.
To examine the difficulties in generating robust clinical evidence and discuss ongoing research.

Main Methods:

Literature review of observational studies and randomized controlled trials.
Analysis of evidence evaluating metastasis-directed therapy.
Discussion of challenges in clinical trial design for oligometastatic disease.

Main Results:

Randomized trials have yielded mixed results, affirming some hypotheses while raising new questions.
Defining oligometastatic disease remains a challenge.
Generating high-quality randomized evidence is complex but essential.

Conclusions:

The role of ablative therapies in oligometastatic cancer requires further investigation through rigorous clinical trials.
Ongoing phase III studies are critical for clarifying treatment efficacy and patient outcomes.
Evidence synthesis highlights the need for precise definitions and robust trial designs.