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Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers

Sheena Pinto1, Jens Pahl1, Arndt Schottelius1

  • 1Affimed GmbH, Heidelberg, Germany.

Trends in Immunology
|October 28, 2022
PubMed

Insights

Multispecific antibodies enhance cancer immunotherapy by directing immune cells to target cancer cells. Novel antibody engineering aims to improve efficacy, especially for solid tumors, by maximizing natural killer (NK) cell potential.

Area of Science:

  • Immunology and Cancer Therapy
  • Antibody Engineering for Targeted Therapies

Background:

  • Multispecific antibodies redirect immune effector cells (NK cells, macrophages, neutrophils) to eliminate cancer cells.
  • Current successes are notable in hematological malignancies, but challenges persist for solid tumors.
  • Limitations include increasing efficacy, overcoming dose-limiting toxicities, and managing immunogenicity.

Purpose of the Study:

  • To discuss novel antibody-engineering strategies.
  • To focus on maximizing the potential of natural killer (NK) cells in cancer immunotherapy.
  • To expand therapeutic options using NK cell engagers.

Main Methods:

  • Review of antibody-engineering developments.
  • Focus on NK cell engagers.
  • Exploration of antibody-dependent cellular cytotoxicity (ADCC) mechanisms.

Main Results:

  • Novel engineering approaches are being developed.
  • Strategies aim to enhance NK cell-mediated anti-tumor activity.
  • Potential for improved therapeutic outcomes in cancer patients.

Conclusions:

  • Advanced antibody engineering can overcome current immunotherapy limitations.
  • Maximizing NK cell engagement is a promising strategy for broader cancer treatment.
  • These developments expand the toolkit for effective cancer immunotherapy.
Keywords:
immunotherapyinnate immunitynatural killer

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