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Published on: September 30, 2021
New indexes derived from routine blood tests and their clinical application in hepatocellular carcinoma
Qing-Qing Luo1, Ting Wang2, Kun-He Zhang2
1Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Insights
Simple clinical indicators can predict hepatocellular carcinoma (HCC) outcomes. Analyzing routine lab results helps create new, easy-to-use indexes for HCC diagnosis, prognosis, and risk assessment.
Area of Science:
- Oncology
- Clinical Chemistry
- Medical Diagnostics
Background:
- Hepatocellular carcinoma (HCC) diagnosis and treatment have advanced, yet patient prognosis remains poor.
- There is a need for accessible, user-friendly indicators for HCC management across all hospital levels.
- HCC development impacts liver function, inflammation, immunity, and nutrition, detectable via routine clinical metrics.
Purpose of the Study:
- To review novel indexes derived from routine clinical indicators for HCC.
- To highlight the utility of these indexes in HCC diagnosis, prognosis, and risk prediction.
- To emphasize the potential of integrated routine data for improving HCC patient outcomes.
Main Methods:
- Comprehensive analysis of routine clinical laboratory indicators.
- Development of new indexes using mathematical modeling and scoring systems.
- Review of recent literature on derived indexes for HCC management.
Main Results:
- Routine clinical indicators reflect systemic changes associated with HCC.
- Derived indexes integrate multiple routine metrics for enhanced predictive power.
- These novel indexes offer improved performance over individual indicators for HCC risk prediction and diagnosis.
Conclusions:
- Comprehensive analysis of routine clinical indicators is crucial for HCC management.
- Derived indexes from routine data offer a practical approach to improving HCC diagnosis and prognosis.
- The development of such accessible indicators is vital for advancing HCC patient care globally.
Abstract:
Considerable efforts have been made in the diagnosis and treatment of hepatocellular carcinoma (HCC), but the prognosis of patients with HCC remains poor. The development of officious and easy-to-use indicators that are applicable to all levels of hospitals for the diagnosis, prognosis and risk prediction of HCC may play an important role in improving the current undesirable situation. The occurrence of HCC can cause a series of local and systemic changes, involving liver function, inflammation, immunity, and nutrition, which can be reflected in routine clinical indicators, especially laboratory metrics. A comprehensive analysis of these routine indicators is capable of providing important information for the clinical management of HCC. Routine clinical indicators are daily medical data that are readily available, easily repeatable, and highly acceptable, which has attracted clinicians to derive a number of comprehensive indexes from routine clinical indicators by means of four arithmetic operations, scoring system, and mathematical modeling. These indexes integrate several clinical indicators into a new single indicator that performs better than any of original individual indicators in the risk prediction, clinical diagnosis and prognostic evaluation of HCC and is easy to use. Herein, we reviewed recent indexes derived from routine clinical indicators for the diagnosis, prognosis and risk prediction of HCC.
