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Enteroviruses: The role of receptors in viral pathogenesis

Emma Heckenberg1, Justin T Steppe2, Carolyn B Coyne3

  • 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States.

Advances in Virus Research
|October 28, 2022
PubMed

Insights

Enteroviruses are common human viruses causing illnesses from mild to severe. This review details their transmission, life cycle, and the cell receptors crucial for infection and disease outcomes.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Enteroviruses are frequent human pathogens causing a wide range of illnesses, from mild to severe.
  • Severe enteroviral infections can manifest as aseptic meningitis, acute liver failure, or acute flaccid myelitis.
  • Cell surface receptors are critical for enterovirus attachment and entry, influencing disease outcomes.

Conclusions:

  • Cell surface receptors are pivotal in the enterovirus life cycle and disease spectrum.
  • Targeting specific receptors may offer therapeutic strategies against enteroviral infections.
  • Further research into enterovirus-receptor dynamics is essential for public health.
Keywords:
EnterovirusEntryPathogenesisReceptors

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