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Motility in auditory sensory cells.

M Ulfendahl

    Acta Physiologica Scandinavica
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Isolated cochlear outer hair cells contract longitudinally and circumferentially when exposed to calcium and ATP. Intact cells also contract with positively charged ferritin or high potassium solutions, supporting the hearing organ

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    Area of Science:

    • Otoacoustic Emissions
    • Cellular Biology
    • Auditory Neuroscience

    Background:

    • Outer hair cells (OHCs) are crucial for hearing sensitivity and frequency selectivity.
    • The motility of OHCs is a key mechanism underlying the amplification process in the cochlea.

    Purpose of the Study:

    • To investigate the contractile responses of isolated cochlear outer hair cells under different experimental conditions.
    • To provide further evidence for the role of OHCs as a motile system in the inner ear.

    Main Methods:

    • Isolated cochlear outer hair cells were subjected to three different procedures to induce contraction.
    • Procedures included permeabilization with calcium and ATP, treatment with positively charged ferritin, and exposure to high potassium solutions.

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    Main Results:

    • Permeabilized cells showed significant shortening (14%) and decreased diameter (12-16%) upon calcium and ATP exposure.
    • Intact cells exhibited shortening (~10%) and increased diameter with positively charged ferritin.
    • High potassium solutions induced rapid contractile responses similar to ferritin treatment.

    Conclusions:

    • Cochlear outer hair cells demonstrate both longitudinal and circumferential contraction.
    • These contractile behaviors support the hypothesis that the hearing organ functions as a motile system.
    • The findings contribute to understanding the cellular mechanisms of hearing.