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Related Concept Videos

Classification of Illness01:17

Classification of Illness

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The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Related Experiment Video

Updated: Aug 23, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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COVID-19: Time for a clinical classification?

Dinesh Jothimani1, Radhika Venugopal1, Shruthi Manoharan1

  • 1Institute of Liver disease and Transplantation, Dr. Rela Institute and Medical Centre, Bharat Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Indian Journal of Pathology & Microbiology
|October 29, 2022
PubMed
Summary
This summary is machine-generated.

A new classification for coronavirus disease 2019 (COVID-19) categorizes patients into asymptomatic, pulmonary, gastrointestinal, and systemic COVID-19 (S-COVID-19) based on pathogenesis and clinical features. This framework aids in understanding disease progression and prognosis.

Keywords:
ACE2COVID-19 classificationGI-COVIDIL6SARS-CoV-2asymptomatic COVID

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Area of Science:

  • Infectious Diseases
  • Pathology
  • Immunology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has evolved with new understandings of asymptomatic transmission and endothelial dysfunction.
  • Existing COVID-19 classifications predate current knowledge, necessitating an updated framework.
  • SARS-CoV-2 pathogenesis involves spike protein binding to ACE2 receptors, leading to cytopathic damage, hyperinflammation, and endothelial injury.

Purpose of the Study:

  • To propose a novel classification system for COVID-19.
  • To integrate pathogenesis and clinical features for a comprehensive understanding of the disease.
  • To stratify patients based on organ involvement, risk, and severity.

Main Methods:

  • Literature review of recent evidence on COVID-19 pathogenesis and clinical manifestations.
  • Development of a classification system based on understanding of ACE2 receptor interaction, cytokine release (IL-6), and thrombotic events.
  • Categorization of patients into asymptomatic, pulmonary, GI, and systemic COVID-19 (S-COVID-19) groups.

Main Results:

  • The proposed classification includes asymptomatic, pulmonary, GI, and systemic COVID-19 (S-COVID-19) categories.
  • Different infectivity and prognosis are observed across these distinct patient groups.
  • Systemic COVID-19 (S-COVID-19) patients exhibit higher risks of critical illness, multi-organ dysfunction, and thrombo-embolic complications.

Conclusions:

  • The new classification provides a better understanding of COVID-19 disease processes.
  • It aids in risk stratification and predicting prognosis based on clinical presentation and pathogenesis.
  • The classification highlights the distinct clinical trajectories and outcomes associated with different COVID-19 phenotypes.