Related Experiment Video

Updated: Aug 23, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

6.9K

Incidence and risk factors for bacterial infection using bortezomib, lenalidomide, and dexamethasone (RVd) in newly

Anisa Bici1, Matthew J Pianko2, Victoria R Nachar3

  • 1Department of Pharmacy Services, Michigan Medicine and the University of Michigan College of Pharmacy, Ann Arbor, MI, USA.

Leukemia & Lymphoma
|October 29, 2022
PubMed

Insights

Bacterial infections occurred in 14.5% of newly diagnosed multiple myeloma patients receiving bortezomib, lenalidomide, and dexamethasone (RVd) induction therapy. Age, smoking, diabetes, prior antibiotic use, and high-risk cytogenetics increased infection risk.

Area of Science:

  • Hematology
  • Oncology
  • Infectious Diseases

Background:

  • Infections are a significant cause of morbidity and mortality in newly diagnosed multiple myeloma (NDMM).
  • The real-world risk of infection with modern induction regimens like bortezomib, lenalidomide, and dexamethasone (RVd) is not well-characterized.
  • Understanding infection risks is crucial for optimizing treatment strategies in NDMM.

Purpose of the Study:

  • To identify the incidence of bacterial infections during first-line RVd induction therapy for NDMM.
  • To determine risk factors associated with bacterial infections in this patient population.
  • To evaluate the severity and outcomes of infections in patients treated with RVd.

Main Methods:

  • Retrospective single-center cohort study.
  • Inclusion of 144 patients with NDMM treated with first-line RVd from January 2014 to January 2020.
  • Collection of demographic and clinical data to identify infections and risk factors.

Main Results:

  • 21 patients (14.5%) experienced bacterial infections during RVd induction.
  • 8 patients (5.5%) had grade 3 infections, despite low antibiotic prophylaxis use (12%).
  • Multivariable analysis identified age, smoking history, diabetes, recent antibiotic use, and high-risk cytogenetics as significant risk factors for infection.

Conclusions:

  • Bacterial infections are a notable concern in NDMM patients undergoing RVd induction.
  • Specific patient characteristics and prior treatments are associated with an increased risk of infection.
  • Further research into prophylactic strategies and risk stratification may improve outcomes.
Keywords:
Infectionantibiotic prophylaxisbacterial infectionsmultiple myelomapneumoniarisk factorstoxicity

More Related Videos

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

8.7K
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.1K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
297
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
397