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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Tablet app-based dexterity training in multiple sclerosis (TAD-MS): a randomized controlled trial.

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Tablet app-based training showed no overall superiority for multiple sclerosis (MS) arm function but improved specific finger dexterity and strength. This home-based intervention offers a viable option for individuals with MS seeking to enhance fine motor skills.

Keywords:
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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Mobile health applications (mHealth) are increasingly used in healthcare.
  • The application of mHealth for multiple sclerosis (MS) has grown, yet specific tools for dexterity training are limited.
  • Dexterity impairment is a common challenge for individuals with MS, impacting daily activities.

Purpose of the Study:

  • To investigate the effectiveness of a tablet app-based home-based training program for improving dexterity in individuals with MS.
  • To compare app-based dexterity training against a control strengthening exercise program.

Main Methods:

  • A randomized controlled trial comparing a 4-week tablet app-based intervention with a control strengthening exercise program.
  • Assessments included the Arm Function in Multiple Sclerosis Questionnaire, dexterous function, grip strength, and quality of life at baseline, post-intervention, and 12-week follow-up.
  • Participants were randomly assigned to either the app group (n=26) or the control group (n=22).

Main Results:

  • No significant difference was observed in the primary endpoint (Arm Function in Multiple Sclerosis Questionnaire) between the app and control groups (p=0.35).
  • The app-based training group showed significant improvements in fine coordinated finger movements and strength compared to the control group.
  • Adherence rates in both interventions exceeded 90%, indicating good compliance.

Conclusions:

  • Tablet app-based training was not superior to a control strengthening program for overall arm and hand function from a patient's perspective.
  • App-based training demonstrated effectiveness in enhancing specific aspects of dexterity, such as finger movements and strength.
  • The home-based nature of app-based training makes it a practical and accessible option for individuals with MS experiencing impaired dexterity.